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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
28/09/2018 |
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Data da última atualização: |
15/01/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SCHNEIDER, R.; MERCANTE, L. A.; ANDRE, R. S.; BRANDÃO, H. M.; MATTOSO, L. H. C.; CORREA, D. S. |
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Afiliação: |
LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Biocompatible electrospun nanofibers containing cloxacillin: Antibacterial activity and effect of PH on the release profile. |
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Ano de publicação: |
2018 |
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Fonte/Imprenta: |
Reactive and Functional Polymers, n. 132, p. 26-35, nov. 2018. |
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ISSN: |
1381-5148 |
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DOI: |
10.1016/j.reactfunctpolym.2018.09.001 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications. MenosAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% o... Mostrar Tudo |
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Palavras-Chave: |
Drug delivery; Electrospinning; Modulated release. |
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Categoria do assunto: |
--
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02706naa a2200241 a 4500
001 2096544
005 2019-01-15
008 2018 bl uuuu u00u1 u #d
022 $a1381-5148
024 7 $a10.1016/j.reactfunctpolym.2018.09.001$2DOI
100 1 $aSCHNEIDER, R.
245 $aBiocompatible electrospun nanofibers containing cloxacillin$bAntibacterial activity and effect of PH on the release profile.$h[electronic resource]
260 $c2018
520 $aAbstract The effectiveness of antibiotics toward resistant strains of bacteria has brought serious concerns related to human and animal health. Controlled drug release systems, especially those based on polymer and polymer-based nanostructures appears as a remarkable approach, once they can potentially improve the therapeutic outcomes toward bacterial infections, while requiring lower amounts of drugs. The current study was designed to investigate the incorporation and release profile of a drug loaded in biodegradable electrospun nanofibrous membranes, based on the drug-polymer interactions, as well as its ability to inhibit bacterial growth. For that purpose, nanofibrous membranes of Ecovio® (EC), a polymer blend composed by poly (lactic acid) (PLA)/poly (butylene adipate-co-terephthalate) (PBAT), loaded with different cloxacillin (CLOX) contents were successfully produced via electrospinning technique. Electrospun nanofibers of EC unloaded and loaded with drug presented smooth surface with a mean diameter close to 600 nm. The physical-chemical characterizations by Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) confirmed the successful drug encapsulation achieved by electrospinning technique. In vitro studies revealed that the developed drug-loaded nanofibrous membrane was successful in inhibiting S. aureus growth. The cumulative release of drug from EC nanofibrous membranes containing 20% of CLOX was demonstrated to be pH dependent, where the antibiotic release rate was much faster for pH 7.3 than that for pH 5.5. In this way, the mechanism involved in the release could be either Fickian or non-Fickian depending on the pH environment. The simple and efficient strategy presented here to develop antimicrobial nanofibrous membrane make them promising for drug delivery carrier and wound dressing applications.
653 $aDrug delivery
653 $aElectrospinning
653 $aModulated release
700 1 $aMERCANTE, L. A.
700 1 $aANDRE, R. S.
700 1 $aBRANDÃO, H. M.
700 1 $aMATTOSO, L. H. C.
700 1 $aCORREA, D. S.
773 $tReactive and Functional Polymers$gn. 132, p. 26-35, nov. 2018.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 29 | |
| 2. |  | PASCHOALIN, R. T.; BRANDÃO, H. M.; ARAÚJO-MOREIRA, F. M.; HERRMANN, P. S. P. Agriculture applications of drug-delivery systems based on ferromagnetic graphite In: INTERNATIONAL CONFERENCE ON FOOD AND AGRICULTURE APPLICATIONS OF NANOTECHNOLOGIES - NanoAgri, 2010, São Pedro, SP. [Anais…] São Pedro: Aptor Software, 2010. Editors: Caue Ribeiro, Odílio Benedito Garrido de Assis, Luiz Henrique Capparelli Mattoso, Sérgio Mascarenhas.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 5. | | ZANETTE, R.; ALMEIDA, L. B. F.; ALMEIDA, C. G.; OLIVEIRA, C. R. de; BRANDÃO, H. M.; MUNK, M. Análise da citoxicidade in vitro das nanofibras de celulose de algodão. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 9., 2017, São Carlos. Anais ... São Carlos: Embrapa Instrumentação, 2017. p.681-684. Editores: Caue Ribeiro de Oliveira, Elaine Cristina Paris, Luiz Henrique Capparelli Mattoso, Marcelo Porto Bemquerer, Maria Alice Martins, Odílio Benedito Garrido de Assis.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 6. | | BRANDÃO, H. M.; SOUSA, R. V.; WOUTERS, F.; PADUA, L. V. R.; MADUREIRA, E. H.; TRALDI, A. S. Avaliação da influência da insulina no processo de luteogênese de ovinos. In: SIMPÓSIO E PÓS-GRADUAÇÃO DO DEPARTAMENTO DE REPRODUÇÃO ANIMAL, 2., 2008, Pirassununga. Anais... Pirassununga: USP, 2008. p. 43| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite. |
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| 8. | | BRANDAO, H. M.; TEIXEIRA, E. M.; ASSUNÇAO, C. M.; CARNEIRO, J.; MARCONCINI, J. M.; MATTOSO, L. H. C. Characterization of polycaprolactone (PCL) after treatment into ruminant digestive system. In: FRENCH-BRAZILIAN MEETING ON POLYMERS - FBPOL, 2., 2008, Florianópolis, SC. Abstracts? Florianópolis: Universidade Federal de Santa Catarina/Centre de Recherches sur les Macromolecules Vegetables, 2008. C35.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 9. | | BRANDÃO, H. M.; MARCONCINI, J. M.; SILVA, S. R. da; BARBOSA, N. R.; TRALDI, A. S.; MADUREIRA, E. H. A potential device for oral vaccination of ruminants In: INTERNATIONAL CONFERENCE ON FOOD AND AGRICULTURE APPLICATIONS OF NANOTECHNOLOGIES - NanoAgri, 2010, São Pedro, SP. [Anais…] São Pedro: Aptor Software, 2010. Editors: Caue Ribeiro, Odílio Benedito Garrido de Assis, Luiz Henrique Capparelli Mattoso, Sérgio Mascarenhas.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 11. | | ZAFALON, L. F.; SANTANA, R. C. M.; PILON, L. E.; BRANDÃO, H. M.; MOSQUEIRA, V. C. F.; TANAKA, E. V. Use of nanoparticulate and convencional antimicrobials for treatment of subclinical mastitis in sheep at drying off. In: WORLD VETERINARY CONGRESS , 31., 2013, Prague. Proceedings... Prague WVA, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 12. | | ZAFALON, L. F.; SANTANA, R. C. M.; PILON, L. E.; BRANDÃO, H. M.; MOSQUEIRA, V. C. F.; TANAKA, E. V. Use of nanoparticulate and convencional antimicrobials for treatment of subclinical in sheep at drying off. WORLD VETERINARY CONGRESS, 31., 2013, Prague. Proceedings... Prague: World Veterinary Association, 2013.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sudeste. |
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| 13. | | BECARO, A. A.; PUTI, F. C.; PANOSSO, A. R.; GERN, J. C.; BRANDÃO, H. M.; CORREA, D. S.; FERREIRA, M. D. Postharvest quality of fresh-cut carrots packaged in plastic films containing silver nanoparticles. Food and bioprocess technology, [S. l.], v. 9, p. 637-649, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 14. | | BECARO, A. A.; PUTI, F. C.; PANOSSO, A. R.; GERN, J. C.; BRANDÃO, H. M.; CORREA, D. S.; FERREIRA, M. D. Postharvest quality of fresh-cut carrots packaged in plastic films containing silver nanoparticles. Food and bioprocess technology, v. 9, p. 637-649, 2016.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 15. | | DA SILVA, S. R.; RAPOSO, N. R. B.; LANGE, C. C.; GERN, J. C.; BRANDI, R. R.; MATTOSO, L. H. C.; RIBEIRO, C.; BRANDÃO, H. M. Obtenção de nanopartículas de própolis e seu efeito antimicrobiano. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 6., 2012, Fortaleza. Anais... São Carlos: Embrapa Instrumentação; Fortaleza: Embrapa Agroindústria Tropical, 2012. p. 351-352. Editores: Maria Alice Martins, MOrsyleide de Freitas Rosa, Men de Sá Moreira de Souza Filho, Nicodemos Moreira dos Santos Junior, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 16. | | ZANETTE, R.; ALMEIDA, L. B. F.; SOUZA, N. L. G. D.; ALMEIDA, C. G.; OLIVEIRA, L. F. C.; OLIVEIRA, C. R. de; BRANDÃO, H. M.; MUNK, M. Preparação, caracterização e citocompatibilidade de filmes nanocompósitos de quitosana e nanofibras de celulose. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 9., 2017, São Carlos. Anais ... São Carlos: Embrapa Instrumentação, 2017. p. 283-286. Editores: Caue Ribeiro de Oliveira, Elaine Cristina Paris, Luiz Henrique Capparelli Mattoso, Marcelo Porto Bemquerer, Maria Alice Martins, Odílio Benedito Garrido de Assis.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Instrumentação. |
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| 17. | | GOUVEIA, A. C. C.; MUNK, M.; OLIVEIRA, V.; FERREIRA, A. P.; BRANDÃO, H. M.; GERN, J. C.; BRAYNER, R.; MARTINS, M. A.; RAPOSO, N. R. B. Preparation, characterization and in vivo biocompatibility studies of cotton cellulose nanofibers. Journal of Nanoscience and Nanotechnology, v. 20, n. 10, 2020. 6532 - 6541| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 18. | | SIQUEIRA, M. C.; AOUADA, M. R. M.; CASTRO, V. L. S.; BRANDÃO, H. M.; RECH, R. R.; MARCONCINI, J. M.; MATTOSO, L. H. C. Caracterização e avaliação da toxicidade de nanopartículas de prata para incorporação em matriz polimérica para uso em embalagens de alimentos. In: WORKSHOP DA REDE DE NANOTECNOLOGIA APLICADA AO AGRONEGÓCIO, 7.; ESCOLA DE NANOTECNOLOGIA, 3., 2013, São Carlos, SP. Anais... São Carlos, SP: Embrapa Instrumentação, 2013. p. 542-544 Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso. CD-ROM. Editores: Maria Alice Martins, Odílio Benedito Garrido de Assis, Caue Ribeiro, Luiz Henrique Capparelli Mattoso.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Leite; Embrapa Instrumentação. |
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| 19. | | MUNK, M.; BRANDÃO, H. M.; NOWAK, S.; MOUTON, L.; GERN, J. C.; GUIMARÃES, A. S.; YÉPRÉMIAN, C.; COUTÉ, A.; RAPOSO, N. R. B.; MARCONCINI, J. M.; BRAYNER, R. Direct and indirect toxic effects of cotton-derived cellulose nanofibers on filamentous green algae. Ecotoxicology and environmental safety, v. 122, p. 399-405, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Instrumentação. |
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| 20. | | GASPAR, E. B.; SANTOS, L. R.; ARAÚJO, F. R.; GULIAS-GOMES, C. C.; LINCOPAN, N.; BRANDÃO, H. M.; ROSINHA, G. M. S. Development of recombinant vaccine against tick fever disease based on chimeric protein of Babesia sp and Anaplasma marginale, associated with nanoparticles adjuvants. In: SIMPÓSIO EMBRAPA LABEX EUA DE SANIDADE ANIMAL, 2., 2012, Brasília, DF. Anais... Brasília, DF: Embrapa Estudos e Capacitação, 2012. p. 153.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| Registros recuperados : 29 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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